I’ve been interested in this topic as well for a UI redesign I’m planning. From what I can find, this answer addresses it succinctly. In short, use the standard fetch API calls to do the networking (interacting with your RESTful service) and Dojo stores to do the data management client-side (a store with fetch calls built into it?). I guess the build system will generate an app that works on browsers that do not support fetch yet, but I’m hoping someone more familiar will corroborate this as true.